Positive regulation of oxidoreductase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of oxidoreductase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PYGL, SH3BP4, and SPEN_S727, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oxidoreductase activity activity versus PYGL in LSCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PYGL →	+0.536	+0.046	<.001	<.001	3	6
BRCA	SH3BP4 →	-0.286	-0.016	<.001	.008	3	5
BRCA	SPEN_S727 →	-0.421	-0.028	.001	.002	3	5
HNSC	TRIM21 →	+0.443	+0.037	.005	.007	3	5
UCEC	TRIM22_S384 →	+0.493	+0.035	.002	.002	3	5
HNSC	STK17A_S28 →	+0.606	+0.043	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051353 vs PYGL — LSCC

Explore this scatter interactively →