Positive regulation of oxidoreductase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGR2, KCNMB4, and TGM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EGR2 grouped by Positive regulation of oxidoreductase activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EGR2 →	+0.973	+1.167	.002	<.001	3	4
KIDNEY	KCNMB4 →	+0.571	+1.215	.002	<.001	3	4
STOMACH	TGM2 →	-3.690	-0.986	.002	.004	2	5
BREAST	TRIP10 →	-1.203	-0.977	<.001	<.001	3	4
BREAST	MCCC2 →	+0.924	+0.842	<.001	<.001	3	4
BREAST	LOXL2 →	-3.414	-0.936	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EGR2 by Positive regulation of oxidoreductase activity activity — KIDNEY

Explore this box plot interactively →