Positive regulation of oxidoreductase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCH1, CYBRD1, and RFK, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oxidoreductase activity activity versus GCH1 in LIVER (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GCH1 →	+1.814	+0.220	.005	.005	3	12
BREAST	CYBRD1 →	-2.522	-0.276	<.001	.006	3	11
BLOOD_Lymphoma	RFK →	+1.049	+0.150	<.001	<.001	3	10
BREAST	ETS1 →	-2.928	-0.230	<.001	<.001	3	9
BREAST	CYFIP2 →	+2.463	+0.207	<.001	<.001	3	9
LUNG_SCLC	FRMD6 →	-2.656	-0.170	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051353 vs GCH1 — LIVER

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