Positive regulation of oxidoreductase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of oxidoreductase activity pathway is significantly associated with the total protein of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are SETD2, SF2, and TFRC, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of oxidoreductase activity activity versus SETD2 in LUNG_SCLC (Pearson r = -0.83).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SETD2 →	-0.257	-0.387	.007	.040	3	1
LUNG_SCLC	SF2 →	-0.332	-0.387	.005	.040	3	1
LUNG_SCLC	TFRC →	+1.633	+0.387	.015	.040	3	1
LUNG_SCLC	Cyclin-B1 →	-0.997	-0.387	.038	.040	3	1
LUNG_SCLC	Porin →	+1.284	+0.387	.034	.040	2	1
LUNG_SCLC	STAT3_pY705 →	+0.612	+0.387	.010	.040	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051353 vs SETD2 — LUNG_SCLC

Explore this scatter interactively →