Positive regulation of lyase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of lyase activity pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM1, PLPBP, and DHRS4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lyase activity activity versus STIM1 in PANCREAS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	STIM1 →	+1.319	+0.328	<.001	.001	3	6
STOMACH	PLPBP →	-0.862	-0.303	<.001	<.001	3	5
LARGE_INTESTINE	DHRS4 →	-0.919	-0.250	.001	<.001	3	4
BLOOD_Leukemia	MBOAT2 →	+2.120	+0.206	<.001	.001	3	4
BLOOD_Leukemia	GPC5 →	+0.477	+0.193	.004	<.001	3	4
BREAST	CORO6 →	+1.408	+0.210	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051349 vs STIM1 — PANCREAS

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