Positive regulation of lyase activity

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of lyase activity pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 40 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Positive regulation of lyase activity pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LGG, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.820	0.334	.003	54	view →
KIRC	DFS	Quartile	IV	0.155	0.459	.001	40	view →
HNSC	OS	Quartile	III,IV	0.642	0.834	.001	34	view →
MESO	OS	Quartile	All	0.288	0.711	<.001	32	view →
BLCA	OS	Quartile	IV	0.262	0.610	.010	30	view →
SKCM	DFS	Tertile	All	0.164	0.307	<.001	30	view →
LGG	DFS	Tertile	All	0.923	0.760	.002	24	view →
UCEC	OS	Quartile	All	0.932	0.826	.005	22	view →
LIHC	DFS	Tertile	All	0.363	0.513	.005	22	view →
ACC	OS	Tertile	IV	0.388	0.961	.010	21	view →
PRAD	DFS	Tertile	All	0.673	0.782	.004	20	view →
LUAD	DFS	Median	All	0.555	0.738	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0051349–UVM (DFS)

Open the UVM breakdown →