Regulation of oxidoreductase activity

Across TCGA patient cohorts, RNA activity of the Regulation of oxidoreductase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARRB2, S100A12, and S100A9_T113, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oxidoreductase activity activity versus ARRB2 in LSCC (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARRB2 →	+0.358	+0.062	<.001	<.001	3	7
GBM	S100A12 →	+1.237	+0.034	<.001	<.001	2	8
BRCA	S100A9_T113 →	+1.227	+0.025	<.001	<.001	3	7
GBM	AMPD3 →	+0.530	+0.033	<.001	<.001	3	7
BRCA	ICAM1 →	+0.616	+0.033	<.001	<.001	3	7
BRCA	IL4I1 →	+0.459	+0.024	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051341 vs ARRB2 — LSCC

Explore this scatter interactively →