Regulation of oxidoreductase activity

Across TCGA patient cohorts, RNA activity of the Regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZXDA, SPATA5L1, and BAG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oxidoreductase activity activity versus ZXDA in PDAC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZXDA →	+0.203	+0.170	.004	.006	3	5
OV	SPATA5L1 →	+0.307	+0.102	.008	.003	3	3
UCEC	BAG5 →	+0.315	+0.157	<.001	<.001	3	3
UCEC	ZNF395 →	+0.501	+0.139	.006	.004	3	3
LUAD	CYP3A43 →	+0.221	+0.166	.003	.003	2	4
GBM	SNORA59A →	+0.531	+0.184	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051341 vs ZXDA — PDAC

Explore this scatter interactively →