Regulation of oxidoreductase activity

Across TCGA cell cohorts, RNA activity of the Regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AZ2, FBXW4, and TNPO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oxidoreductase activity activity versus H2AZ2 in LUNG_SCLC (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	H2AZ2 →	-0.668	-0.280	<.001	.001	3	5
SKIN	FBXW4 →	-0.691	-0.177	.001	.001	3	4
SOFT_TISSUE	TNPO1 →	+1.267	+0.315	.004	.002	3	4
OESOPHAGUS	CDK5RAP3 →	-0.910	-0.184	<.001	<.001	3	4
LUNG_SCLC	SHROOM3 →	-1.615	-0.195	<.001	<.001	3	4
STOMACH	TMC4 →	-3.034	-0.185	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051341 vs H2AZ2 — LUNG_SCLC

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