Metaphase chromosome alignment

Across TCGA cell cohorts, RNA activity of the Metaphase chromosome alignment pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF653, EVL, and GINS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metaphase chromosome alignment activity versus ZNF653 in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF653 →	+0.670	+0.155	.001	.004	3	6
BLOOD_Myeloma	EVL →	+3.997	+0.157	<.001	<.001	3	5
BLOOD_Leukemia	GINS1 →	+0.821	+0.157	<.001	<.001	3	4
BLOOD_Leukemia	TRIM62 →	+0.729	+0.192	<.001	.006	3	4
BLOOD_Leukemia	RIMS3 →	+1.519	+0.183	<.001	.009	3	4
LUNG_SCLC	STMN1 →	+1.155	+0.194	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051310 vs ZNF653 — LUNG_SCLC

Explore this scatter interactively →