Meiotic chromosome separation

Across TCGA patient cohorts, RNA activity of the Meiotic chromosome separation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, RFC1_S368, and RFC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic chromosome separation activity versus RFC4 in LSCC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	+0.515	+0.108	<.001	<.001	3	10
LUAD	RFC1_S368 →	+1.071	+0.165	<.001	<.001	3	9
BRCA	RFC2 →	+0.422	+0.082	<.001	<.001	3	9
LUAD	RRM2 →	+0.988	+0.161	<.001	<.001	3	9
LSCC	RRP1 →	+0.376	+0.114	<.001	<.001	3	9
BRCA	RRP1B →	+0.465	+0.059	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051307 vs RFC4 — LSCC

Explore this scatter interactively →