Mitotic sister chromatid separation

Across TCGA patient cohorts, RNA activity of the Mitotic sister chromatid separation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPI, NEK2, and NCAPH, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic sister chromatid separation activity versus CENPI in UCEC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPI →	+0.776	+0.805	<.001	<.001	3	8
BRCA	NEK2 →	+1.042	+0.740	<.001	<.001	3	8
BRCA	NCAPH →	+0.898	+0.841	<.001	<.001	3	8
OV	SGO1 →	+0.962	+1.014	<.001	<.001	3	8
LSCC	FANCI →	+1.052	+1.083	<.001	<.001	3	8
UCEC	TICRR →	+0.917	+0.893	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051306 vs CENPI — UCEC

Explore this scatter interactively →