Mitotic sister chromatid separation

Across TCGA pan-cancer cohorts, RNA activity of the Mitotic sister chromatid separation pathway differs between tumor and matched normal tissue in 17 of the 18 cancer types tested.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA, show the opposite pattern, with lower activity in tumor tissue.

HNSC, BLCA, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
HNSC	Male	IV	+0.116	<.001	12	view →
BLCA	Male	III,IV	+0.181	<.001	11	view →
KIRP	All	III,IV	+0.091	<.001	11	view →
KIRC	Male	IV	+0.082	<.001	11	view →
COAD	Male	II,III,IV	+0.068	<.001	10	view →
LUSC	Female	II,III,IV	+0.218	<.001	9	view →
STAD	Female	All	+0.192	<.001	9	view →
LUAD	Male	III,IV	+0.181	<.001	9	view →
LIHC	Male	All	+0.099	<.001	9	view →
UCEC	All	III,IV	+0.202	<.001	8	view →
KICH	Male	II,III,IV	+0.096	.003	7	view →
BRCA	All	II,III,IV	+0.143	<.001	6	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 17 lineages.

GO:0051306–HNSC

Open the HNSC breakdown →