Mitotic sister chromatid separation

Across TCGA cell cohorts, RNA activity of the Mitotic sister chromatid separation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM7, FAAH, and SYPL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM7 grouped by Mitotic sister chromatid separation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RBM7 →	+1.020	+0.247	.002	<.001	3	4
LIVER	FAAH →	-3.090	-0.258	<.001	.009	3	4
SOFT_TISSUE	SYPL1 →	+0.679	+0.414	.001	<.001	3	3
SOFT_TISSUE	TXNDC9 →	+0.778	+0.495	.001	.005	3	2
SOFT_TISSUE	MAD2L2 →	-0.953	-0.361	.001	.004	3	2
LIVER	PNN →	-1.343	-0.247	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM7 by Mitotic sister chromatid separation activity — LIVER

Explore this box plot interactively →