Mitotic sister chromatid separation

Across TCGA cell cohorts, RNA activity of the Mitotic sister chromatid separation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM21, IFITM3, and SUMF1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic sister chromatid separation activity versus TRIM21 in LUNG_SCLC (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRIM21 →	-1.998	-1.211	.006	.009	3	2
LUNG_SCLC	IFITM3 →	-2.490	-1.061	.006	.005	3	2
LUNG_SCLC	SUMF1 →	-0.861	-1.046	.004	.006	3	2
LUNG_SCLC	ACSS1 →	-2.838	-1.505	.001	.003	3	2
LUNG_SCLC	PSG4 →	-0.106	-1.578	.002	<.001	3	2
LUNG_SCLC	SNURF →	-5.029	-1.769	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051306 vs TRIM21 — LUNG_SCLC

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