Chromosome movement towards spindle pole

Across TCGA patient cohorts, RNA activity of the Chromosome movement towards spindle pole pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL15, KDF1, and SNRPD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome movement towards spindle pole activity versus MRPL15 in LSCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRPL15 →	-0.567	-0.077	.001	<.001	3	4
LSCC	KDF1 →	-0.374	-0.053	.003	<.001	3	4
GBM	SNRPD2 →	-0.192	-0.589	.008	<.001	3	4
GBM	DLEC1 →	+0.502	+0.554	<.001	.001	3	4
UCEC	CDKN3 →	-0.499	-0.774	.007	.002	3	4
UCEC	PDCL3 →	-1.009	-0.966	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051305 vs MRPL15 — LSCC

Explore this scatter interactively →