Chromosome movement towards spindle pole

Across TCGA cell cohorts, RNA activity of the Chromosome movement towards spindle pole pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ID3, MAN2A2, and CDKL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ID3 grouped by Chromosome movement towards spindle pole-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ID3 →	+2.221	+0.305	.006	.008	3	3
UPPER_AERODIGESTIVE_TRACT	MAN2A2 →	-1.495	-0.246	.008	.001	3	3
LUNG_NSCLC_LUSC	CDKL3 →	-1.347	-0.262	<.001	.008	3	3
LUNG_NSCLC_LUSC	TBX21 →	+0.058	+0.192	.004	.005	3	3
BONE	DTX3L →	+2.615	+0.273	.002	.006	2	4
BLOOD_Leukemia	PPP1R14C →	+1.624	+1.128	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ID3 by Chromosome movement towards spindle pole activity — PANCREAS

Explore this box plot interactively →