Chromosome movement towards spindle pole

Across TCGA cell cohorts, RNA activity of the Chromosome movement towards spindle pole pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC14L2, PHLDB2, and JPH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome movement towards spindle pole activity versus SEC14L2 in BREAST (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SEC14L2 →	-1.888	-0.187	<.001	.001	3	4
LARGE_INTESTINE	PHLDB2 →	-3.483	-0.255	.003	<.001	3	4
PANCREAS	JPH2 →	-2.161	-0.165	.001	<.001	3	4
LARGE_INTESTINE	ZBED2 →	-2.445	-0.196	.005	<.001	3	4
OESOPHAGUS	SEPTIN6 →	-1.718	-0.199	.002	.003	3	4
LUNG_NSCLC_LUAD	SHPRH →	+0.467	+0.110	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051305 vs SEC14L2 — BREAST

Explore this scatter interactively →