Chromosome separation

Across TCGA cell cohorts, RNA activity of the Chromosome separation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTRN, NAGK, and GPR137B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UTRN grouped by Chromosome separation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UTRN →	-1.188	-0.890	.007	.004	3	4
SKIN	NAGK →	-0.383	-0.767	.006	.009	3	4
CNS	GPR137B →	-1.083	-0.431	<.001	.004	3	4
LUNG_NSCLC_LUSC	SLA →	+0.080	+0.261	.002	.007	3	3
STOMACH	OBSL1 →	-2.939	-0.656	<.001	.009	2	4
BLOOD_Leukemia	PDLIM1 →	-3.952	-1.227	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UTRN by Chromosome separation activity — PANCREAS

Explore this box plot interactively →