Chromosome separation

Across TCGA cell cohorts, RNA activity of the Chromosome separation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM198, SMIM1, and ANP32B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chromosome separation activity versus TMEM198 in KIDNEY (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TMEM198 →	-1.225	-0.351	<.001	.001	3	4
KIDNEY	SMIM1 →	-1.585	-0.351	.003	.001	3	4
LUNG_SCLC	ANP32B →	+0.534	+0.430	<.001	.008	3	4
KIDNEY	ACAT2 →	+1.491	+0.346	.008	.002	3	4
KIDNEY	PIN1 →	+0.674	+0.346	.008	.002	3	4
BLOOD_Leukemia	DDX24 →	+0.484	+0.589	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051304 vs TMEM198 — KIDNEY

Explore this scatter interactively →