Centrosome separation

Across TCGA patient cohorts, RNA activity of the Centrosome separation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO5, MIR548V, and CENPA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centrosome separation activity versus FBXO5 in OV (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FBXO5 →	+0.609	+0.656	.001	<.001	3	3
LSCC	MIR548V →	-0.567	-0.154	.009	.006	3	3
OV	CENPA →	+0.995	+0.688	<.001	<.001	3	3
OV	UVRAG-DT →	+0.281	+0.598	.003	<.001	3	3
OV	HMMR →	+1.101	+0.585	<.001	.003	3	3
OV	AURKA →	+0.651	+0.609	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051299 vs FBXO5 — OV

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