Establishment of meiotic spindle localization

Across TCGA patient cohorts, RNA activity of the Establishment of meiotic spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUGCT-AS1, GAS1, and INHBA-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of meiotic spindle localization activity versus SUGCT-AS1 in LSCC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUGCT-AS1 →	+0.472	+0.420	<.001	.002	3	5
PDAC	GAS1 →	+0.963	+0.442	.001	.007	3	4
PDAC	INHBA-AS1 →	+0.416	+0.431	.007	.008	2	5
PDAC	OR7E128P →	-0.251	-0.323	.009	.007	3	4
LSCC	LGALS1 →	+0.792	+0.493	<.001	<.001	3	4
LSCC	RASGRF2 →	+0.479	+0.460	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051295 vs SUGCT-AS1 — LSCC

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