Establishment of meiotic spindle localization

Across TCGA cell cohorts, RNA activity of the Establishment of meiotic spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMD3, TRIM37, and GAPDH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMD3 grouped by Establishment of meiotic spindle localization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PSMD3 →	-0.498	-0.357	.002	.007	3	3
LUNG_NSCLC_LUSC	TRIM37 →	-0.743	-0.408	.003	.001	3	3
LUNG_NSCLC_LUSC	GAPDH →	-1.065	-0.441	.003	.006	2	4
LUNG_NSCLC_LUSC	SNX17 →	-1.181	-0.629	<.001	<.001	3	3
LUNG_NSCLC_LUSC	KDM3B →	-0.791	-0.460	.006	.004	3	3
LUNG_NSCLC_LUSC	TUBG1 →	-0.741	-0.449	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMD3 by Establishment of meiotic spindle localization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →