Establishment of meiotic spindle localization

Across TCGA cell cohorts, RNA activity of the Establishment of meiotic spindle localization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKA1, WDR62, and SPC25, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of meiotic spindle localization activity versus SKA1 in BREAST (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SKA1 →	+1.076	+0.100	<.001	<.001	3	15
PANCREAS	WDR62 →	+1.028	+0.093	.001	.004	3	12
UPPER_AERODIGESTIVE_TRACT	SPC25 →	+1.146	+0.116	<.001	.003	3	12
BLOOD_Myeloma	SKA3 →	+1.497	+0.250	.001	.003	3	11
LIVER	PBK →	+1.674	+0.129	<.001	<.001	3	11
BREAST	HMGB1 →	+0.890	+0.089	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051295 vs SKA1 — BREAST

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