Nuclear pore complex assembly

Across TCGA patient cohorts, RNA activity of the Nuclear pore complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO5, MSH6, and NUP93, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore complex assembly activity versus XPO5 in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO5 →	+0.514	+0.044	<.001	<.001	3	8
LSCC	MSH6 →	+0.570	+0.048	.001	.007	3	8
LSCC	NUP93 →	+0.189	+0.060	<.001	<.001	3	8
HNSC	SMC5 →	+0.190	+0.086	.001	<.001	3	7
PDAC	TOP2A_S1377 →	+0.954	+0.049	<.001	<.001	3	7
GBM	ZC3H18 →	+0.289	+0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051292 vs XPO5 — LSCC

Explore this scatter interactively →