Protein heterotetramerization

Across TCGA patient cohorts, RNA activity of the Protein heterotetramerization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, TACC3_S71, and TK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein heterotetramerization activity versus TOP2A in UCEC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOP2A →	+0.709	+0.084	<.001	<.001	3	7
OV	TACC3_S71 →	+0.967	+0.041	.009	.008	3	6
HNSC	TK1 →	+0.524	+0.083	.002	.005	3	6
UCEC	TOP2A_S1377 →	+1.039	+0.149	<.001	<.001	3	6
GBM	PRIM2 →	+0.463	+0.056	.004	.002	3	6
UCEC	RRM2 →	+0.855	+0.090	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051290 vs TOP2A — UCEC

Explore this scatter interactively →