Protein homotetramerization

Across TCGA patient cohorts, RNA activity of the Protein homotetramerization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1, ITGAL, and STAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein homotetramerization activity versus FMNL1 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FMNL1 →	+0.442	+0.029	.005	.004	3	5
CCRCC	ITGAL →	+0.584	+0.037	<.001	<.001	3	5
CCRCC	STAT2 →	+0.379	+0.038	<.001	<.001	3	5
GBM	NNMT →	+1.093	+0.030	<.001	.003	3	5
OV	PECAM1 →	+0.444	+0.035	<.001	<.001	3	5
LUAD	PREX1 →	+0.245	+0.026	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051289 vs FMNL1 — GBM

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