Protein homotetramerization

Across TCGA pan-cancer cohorts, RNA activity of the Protein homotetramerization pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 59 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Protein homotetramerization pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRC, and THYM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.482	0.279	<.001	74	view →
KIRC	OS	Median	All	0.544	0.750	<.001	54	view →
THYM	OS	Quartile	All	0.562	1.000	<.001	43	view →
SKCM	OS	Tertile	All	0.382	0.236	<.001	40	view →
LGG	DFS	Median	All	0.642	0.796	<.001	39	view →
ACC	DFS	Median	IV	0.075	0.499	<.001	31	view →
ESCA	OS	Tertile	III,IV	0.712	0.327	.004	22	view →
GBM	DFS	Quartile	All	0.181	0.327	.004	12	view →
CHOL	DFS	Tertile	II,III,IV	0.119	0.405	.006	12	view →
PAAD	OS	Median	All	0.678	0.385	.012	10	view →
BLCA	DFS	Median	IV	0.385	0.535	.018	10	view →
KIRP	OS	Median	All	0.494	0.812	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0051289–HNSC (OS)

Open the HNSC breakdown →