Protein homotetramerization

Across TCGA patient cohorts, RNA activity of the Protein homotetramerization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM78A, RASAL3, and MS4A6A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein homotetramerization activity versus FAM78A in HNSC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FAM78A →	+0.664	+0.208	<.001	<.001	3	8
LSCC	RASAL3 →	+0.767	+0.221	<.001	<.001	3	8
UCEC	MS4A6A →	+0.776	+0.178	<.001	<.001	3	8
HNSC	WDFY4 →	+0.748	+0.204	<.001	<.001	3	8
HNSC	CXCR6 →	+0.687	+0.173	<.001	<.001	3	8
HNSC	SPN →	+0.858	+0.205	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051289 vs FAM78A — HNSC

Explore this scatter interactively →