Protein homotetramerization

Across TCGA cell cohorts, RNA activity of the Protein homotetramerization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC85B, KCTD3, and LARP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC85B grouped by Protein homotetramerization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CCDC85B →	-1.156	-0.216	.004	.001	3	5
BREAST	KCTD3 →	+0.898	+0.235	<.001	.004	3	4
LUNG_SCLC	LARP6 →	-1.219	-0.189	.001	<.001	3	4
LUNG_SCLC	MTARC1 →	+1.919	+0.191	.002	<.001	3	4
STOMACH	ANKRD18A →	-1.252	-0.238	.004	<.001	3	4
BLOOD_Lymphoma	PPP5C →	+0.879	+0.309	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC85B by Protein homotetramerization activity — OESOPHAGUS

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