Protein homotetramerization

Across TCGA cell cohorts, RNA activity of the Protein homotetramerization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAP1, GBP1, and STAT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein homotetramerization activity versus TAP1 in LIVER (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TAP1 →	+2.940	+0.173	.002	.001	3	8
BREAST	GBP1 →	+2.182	+0.191	.001	.002	3	7
BREAST	STAT1 →	+0.988	+0.170	<.001	<.001	3	7
LIVER	TAPBP →	+1.511	+0.169	.006	.005	2	8
BREAST	ABHD4 →	+0.978	+0.190	.002	.001	3	6
BREAST	MX1 →	+2.621	+0.210	.007	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051289 vs TAP1 — LIVER

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