Protein complex oligomerization

Across TCGA patient cohorts, RNA activity of the Protein complex oligomerization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAAO, UBL4A, and DDX49, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HAAO grouped by Protein complex oligomerization-low versus -high activity in BRCA.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HAAO →	-2.250	-0.286	.004	.002	3	2
COAD	UBL4A →	-0.430	-0.227	.001	.003	3	1
COAD	DDX49 →	-0.327	-0.168	.001	.002	3	1
COAD	ARMC6 →	-0.396	-0.200	<.001	<.001	3	1
COAD	C19orf25 →	-0.426	-0.222	.005	.001	3	1
COAD	CCRL2 →	-0.415	-0.154	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051259 vs HAAO — BRCA

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