Negative regulation of lymphocyte activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, PSMB9, and TAP1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte activation activity versus HLA-B in BONE (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HLA-B →	+4.106	+0.074	<.001	<.001	3	17
BONE	PSMB9 →	+3.211	+0.078	<.001	<.001	3	17
LUNG_SCLC	TAP1 →	+2.195	+0.067	<.001	<.001	3	16
BONE	PSMB8 →	+3.034	+0.069	.001	<.001	3	16
BONE	HLA-C →	+3.065	+0.064	<.001	<.001	3	16
LUNG_NSCLC_LUSC	HLA-E →	+2.777	+0.078	.008	.001	1	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051250 vs HLA-B — BONE

Explore this scatter interactively →