Spindle elongation

Across TCGA patient cohorts, RNA activity of the Spindle elongation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, KIF14, and KIF18A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle elongation activity versus LMNB1 in OV (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LMNB1 →	+1.494	+1.068	<.001	<.001	3	9
BRCA	KIF14 →	+0.980	+0.896	<.001	<.001	3	9
OV	KIF18A →	+1.076	+0.688	<.001	.003	3	9
BRCA	HJURP →	+1.096	+0.799	<.001	<.001	3	9
OV	KIF23 →	+1.082	+0.783	<.001	<.001	3	9
BRCA	KIF11 →	+0.909	+0.975	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051231 vs LMNB1 — OV

Explore this scatter interactively →