Spindle assembly

Across TCGA patient cohorts, RNA activity of the Spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, TOP2A_S1247, and RACGAP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle assembly activity versus TOP2A in LUAD (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A →	+1.256	+0.105	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.581	+0.092	<.001	<.001	3	10
LUAD	RACGAP1 →	+0.913	+0.097	<.001	<.001	3	10
BRCA	CHEK1 →	+0.761	+0.048	<.001	<.001	3	9
GBM	RFC2 →	+0.625	+0.091	<.001	<.001	3	9
LUAD	RPL12_S38 →	+1.282	+0.090	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051225 vs TOP2A — LUAD

Explore this scatter interactively →