Spindle assembly

Across TCGA cell cohorts, RNA activity of the Spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP29, KRT80, and PMEPA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle assembly activity versus ARHGAP29 in BONE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARHGAP29 →	+4.276	+0.286	.001	.004	3	7
BONE	KRT80 →	+4.108	+0.336	.003	.001	3	6
SOFT_TISSUE	PMEPA1 →	+3.337	+0.320	.002	.001	3	6
OVARY	UQCR11 →	-0.693	-0.268	.001	.003	2	6
OVARY	RPS27L →	-1.517	-0.246	.002	.003	3	5
OVARY	MT-ND3 →	+0.783	+0.226	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051225 vs ARHGAP29 — BONE

Explore this scatter interactively →