Protein insertion into membrane

Across TCGA patient cohorts, RNA activity of the Protein insertion into membrane pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF125, FRZB, and ABCA8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into membrane activity versus RNF125 in HNSC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF125 →	-0.652	-0.250	.007	<.001	3	6
BRCA	FRZB →	-0.924	-0.185	<.001	<.001	3	6
BRCA	ABCA8 →	-0.769	-0.143	<.001	<.001	3	5
BRCA	CCDC173 →	-0.453	-0.155	.002	.001	3	5
CCRCC	SHROOM4 →	-0.647	-0.268	<.001	<.001	3	5
BRCA	ARHGEF40 →	-0.606	-0.163	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051205 vs RNF125 — HNSC

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