Protein insertion into membrane

Across TCGA cell cohorts, RNA activity of the Protein insertion into membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FARSA, MPP6, and GPR156, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into membrane activity versus FARSA in BLOOD_Lymphoma (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FARSA →	+0.934	+0.071	<.001	<.001	3	11
LARGE_INTESTINE	MPP6 →	+1.192	+0.054	<.001	<.001	3	11
OESOPHAGUS	GPR156 →	+1.135	+0.112	.001	<.001	3	10
OESOPHAGUS	TMEM121 →	+1.607	+0.086	<.001	<.001	3	10
OESOPHAGUS	RTL5 →	+0.984	+0.077	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	TIMM8A →	+0.961	+0.076	.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051205 vs FARSA — BLOOD_Lymphoma

Explore this scatter interactively →