Protein insertion into membrane

Across TCGA cell cohorts, RNA activity of the Protein insertion into membrane pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAP2, SGCB, and MAN1A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into membrane activity versus STAP2 in SOFT_TISSUE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	STAP2 →	+1.635	+0.257	.008	<.001	3	5
SKIN	SGCB →	-1.124	-0.173	<.001	.005	3	5
OESOPHAGUS	MAN1A1 →	-1.806	-0.205	.004	.006	3	4
KIDNEY	TRNT1 →	+0.799	+0.300	.004	.004	3	4
LARGE_INTESTINE	BBS7 →	-1.118	-0.300	<.001	<.001	3	4
OVARY	SPATA5 →	-1.149	-0.243	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051205 vs STAP2 — SOFT_TISSUE

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