Prosthetic group metabolic process

Across TCGA patient cohorts, RNA activity of the Prosthetic group metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MOCOS_S530, PIK3R1_S154, and MAGED2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prosthetic group metabolic process activity versus MOCOS_S530 in CCRCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MOCOS_S530 →	+0.853	+0.072	<.001	<.001	3	4
GBM	PIK3R1_S154 →	-0.904	-0.078	.002	.003	3	4
CCRCC	MAGED2 →	+0.229	+0.059	<.001	<.001	3	4
BRCA	SUOX →	+0.373	+0.031	<.001	<.001	3	4
LUAD	GTF3C1_S754 →	+0.349	+0.055	<.001	.001	3	4
BRCA	RREB1_S161 →	-0.378	-0.040	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051189 vs MOCOS_S530 — CCRCC

Explore this scatter interactively →