Vitamin transport

Across TCGA patient cohorts, RNA activity of the Vitamin transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBA2, SCAF1, and RNMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin transport activity versus UBA2 in GBM (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UBA2 →	-0.320	-0.057	<.001	<.001	3	5
LSCC	SCAF1 →	-0.218	-0.033	.002	.005	3	4
PDAC	RNMT →	-0.128	-0.037	.007	<.001	3	4
GBM	TOP1 →	-0.329	-0.053	.001	.001	3	4
LSCC	CHD8_S2071 →	-0.609	-0.059	.007	.005	3	4
PDAC	HNRNPLL_S68 →	-0.543	-0.086	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051180 vs UBA2 — GBM

Explore this scatter interactively →