Vitamin transport

Across TCGA patient cohorts, RNA activity of the Vitamin transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCAT, ST3GAL4, and AGAP2-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin transport activity versus GCAT in OV (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GCAT →	-0.564	-0.257	<.001	.005	3	4
CCRCC	ST3GAL4 →	-0.392	-0.182	.006	.004	3	4
BRCA	AGAP2-AS1 →	-0.322	-0.434	.002	.009	2	5
LSCC	OMD →	-0.675	-0.545	<.001	<.001	3	3
LSCC	PLIN2 →	+0.597	+0.776	.006	<.001	3	3
LSCC	EPHB1 →	+0.718	+0.697	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051180 vs GCAT — OV

Explore this scatter interactively →