Vitamin transport

Across TCGA patient cohorts, RNA activity of the Vitamin transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCARB1, SLC2A1, and SEC62, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin transport activity versus SCARB1 in PDAC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SCARB1 →	+0.462	+1.094	<.001	<.001	3	4
COAD	SLC2A1 →	+0.847	+0.307	<.001	<.001	3	4
UCEC	SEC62 →	+0.695	+0.927	<.001	<.001	3	3
UCEC	SLC12A7 →	+0.472	+0.719	<.001	<.001	3	3
COAD	SLC2A1_T478 →	+0.697	+0.265	<.001	<.001	3	3
UCEC	SLC44A2 →	+0.371	+0.532	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051180 vs SCARB1 — PDAC

Explore this scatter interactively →