Vitamin transport

Across TCGA cell cohorts, RNA activity of the Vitamin transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, SLC2A1, and FLNA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin transport activity versus NRP1 in LIVER (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NRP1 →	+3.457	+1.668	.002	<.001	3	6
LARGE_INTESTINE	SLC2A1 →	+2.945	+1.343	<.001	<.001	3	6
LARGE_INTESTINE	FLNA →	+2.219	+1.146	<.001	.003	3	5
LUNG_NSCLC_LUSC	PYCR1 →	-2.177	-1.558	.003	.008	3	4
BREAST	KHK →	-0.840	-0.784	<.001	.002	3	4
BREAST	FZD7 →	+1.454	+0.807	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051180 vs NRP1 — LIVER

Explore this scatter interactively →