Meiotic sister chromatid cohesion

Across TCGA patient cohorts, RNA activity of the Meiotic sister chromatid cohesion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZC3H13_S1438, RBM15_S259, and SIN3A_S860, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic sister chromatid cohesion activity versus ZC3H13_S1438 in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZC3H13_S1438 →	+0.442	+0.784	<.001	.001	3	4
OV	RBM15_S259 →	+1.095	+1.420	.006	.003	3	4
GBM	SIN3A_S860 →	+0.465	+0.503	.001	.004	3	3
GBM	CDC5L →	+0.269	+0.457	<.001	<.001	3	3
GBM	IWS1_S511 →	+0.394	+0.586	<.001	<.001	3	3
GBM	PPIG_T611 →	+0.777	+0.773	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051177 vs ZC3H13_S1438 — UCEC

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