Meiotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Meiotic sister chromatid cohesion pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTN5, TRIM53AP, and CYP4B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTN5 grouped by Meiotic sister chromatid cohesion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNTN5 →	-0.260	-0.160	.002	.002	3	4
BLOOD_Leukemia	TRIM53AP →	-0.274	-0.122	<.001	<.001	3	4
SOFT_TISSUE	CYP4B1 →	+0.325	+0.136	<.001	<.001	3	4
SOFT_TISSUE	THAP4 →	+0.392	+0.184	.005	<.001	3	4
KIDNEY	PHACTR1 →	+0.162	+0.123	.004	.004	3	4
SKIN	RPS6KA3 →	-0.109	-0.083	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTN5 by Meiotic sister chromatid cohesion activity — BLOOD_Leukemia

Explore this box plot interactively →