Meiotic sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Meiotic sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF10A, EIF3I, and MRPL57, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic sister chromatid cohesion activity versus TNFRSF10A in KIDNEY (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TNFRSF10A →	-1.182	-0.337	.006	.002	3	5
PANCREAS	EIF3I →	-0.855	-0.235	.001	.007	2	5
UPPER_AERODIGESTIVE_TRACT	MRPL57 →	-0.994	-0.173	.005	.002	3	4
LUNG_NSCLC_LUAD	SMIM12 →	-0.359	-0.136	.006	.003	3	4
PANCREAS	FXN →	-1.524	-0.293	<.001	<.001	3	4
BLOOD_Myeloma	PRICKLE3 →	-0.590	-0.156	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051177 vs TNFRSF10A — KIDNEY

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