Import into nucleus

Across TCGA cell cohorts, RNA activity of the Import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARPBP, CCNYL1, and CHD9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARPBP grouped by Import into nucleus-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PARPBP →	-0.811	-0.171	.004	.001	3	5
SKIN	CCNYL1 →	-0.489	-0.183	.007	.003	2	5
BLOOD_Leukemia	CHD9 →	-0.661	-0.149	.004	.002	3	4
LUNG_NSCLC_LUAD	TXNL4B →	-0.437	-0.097	.001	.004	3	4
SKIN	ABI2 →	-0.656	-0.210	.004	<.001	3	3
KIDNEY	KATNB1 →	-0.735	-0.182	.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARPBP by Import into nucleus activity — PANCREAS

Explore this box plot interactively →