Nuclear export

Across TCGA patient cohorts, RNA activity of the Nuclear export pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, MAP1B_S1438, and PCGF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear export activity versus MAP1B in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+0.913	+0.036	<.001	<.001	3	6
LSCC	MAP1B_S1438 →	+1.009	+0.029	<.001	.001	3	5
PDAC	PCGF1 →	+0.880	+0.050	.001	.002	3	5
LSCC	RPL26 →	-0.644	-0.049	<.001	<.001	3	5
LSCC	RPL6 →	-0.301	-0.029	<.001	<.001	3	5
CCRCC	VPS13C_S737 →	-0.431	-0.037	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051168 vs MAP1B — LSCC

Explore this scatter interactively →