Nuclear export

Across TCGA cell cohorts, RNA activity of the Nuclear export pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP188, FUBP3, and UBTF, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear export activity versus NUP188 in SOFT_TISSUE (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NUP188 →	+1.275	+0.112	<.001	<.001	3	20
STOMACH	FUBP3 →	+0.914	+0.109	<.001	<.001	3	20
LARGE_INTESTINE	UBTF →	+1.221	+0.097	<.001	<.001	3	20
BLOOD_Lymphoma	MGA →	+1.559	+0.107	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	ERCC3 →	+0.820	+0.062	<.001	.005	3	19
BREAST	TNRC6A →	+1.058	+0.086	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051168 vs NUP188 — SOFT_TISSUE

Explore this scatter interactively →